论文摘要修改实例详解

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今天，我们用一篇已经发表了，但还有很大改善空间的论文，作为实例进行实战演练。所谓实战演练，就是把论文的关键部分拿出来，我们在分析的同时把它修改好，甚至是把论文的某一些关键内容重写出来。

论文的标题：

Clinicopathological analysis of 67 cases of esophageal neuroendocrine carcinoma and the effect of postoperative adjuvant therapy on prognosis

修改后的标题：

Association of postoperative adjuvant chemotherapy with prognosis in patients undergoing curative resection for esophageal neuroendocrine carcinoma: a retrospective analysis of 67 cases

下面是论文的摘要部分，通过分析摘要部分达成两个目的：第一，了解这个研究具体是怎么做的，核心结果是什么；第二，把摘要的主体部分修改出来。

摘要分成四个基本部分，摘要原文：

The clinicopathological properties of esophageal neuroendocrine carcinoma (ENEC) and its optimal therapy have not been widely studied, as the disease is not common. Consequently, we conducted a retrospective study to analyze the clinical features as well as the prognosis of patients with surgically resected ENEC.

The clinicopathological data of patients with ENEC who underwent esophagostomy with regional lymphadenectomy at XXX starting January 2008 until December 2014 were collected.

Ninety-two cases of ENEC were part of this study. However, only 67 patients were analyzed and followed up. A univariate model for the Cox proportional hazards revealed that prognosis was associated with postoperative adjuvant therapy, age, and lymph node metastasis (P<.05); a multivariate Cox proportional hazards model showed that postoperative adjuvant therapy was a significant independent prognostic factor. Postoperative adjuvant therapy directly affected overall survival, with a significant disparity noted between the groups (P = .022). In this study, patients who received adjuvant therapy had an average time of survival of 39 months (interquartile range: 27.068–50.932months), while those who did not receive adjuvant therapy had an average survival time of 13 months (interquartile range:10.129–15.871months). The survival time was longer in the treated group than in the untreated group (hazard ratio=0.47; 95% confidence interval: 0.23–0.94; P=.034).

ENEC is a heterogeneous tumor with a very poor prognosis. Combining surgery with adjuvant and/or chemotherapy significantly prolongs the survival of patients, and the optimal treatment for ENEC should be determined with future prospective studies.

修改后的摘要部分：

The clinicopathological properties of esophageal neuroendocrine carcinoma (ENEC) and its optimal therapy have not been widely studied, as the disease is not common. We conducted a retrospective study to identify risk factors for poor prognosis in patients undergoing curative resection of ENEC.

We screened all cases of curative resection of esophagectomy plus regional lymphadenectomy for ENEC at xxxx starting January 2008 until December 2014. Multivariate regression was conducted using a Cox proportional hazards model.

Screening of the medical records identified 92 patients undergoing curative resection for ENEC. Twenty-five were lost to follow-up, and the remaining 67 patients (????, 57 men) were included in the final analysis. In univariate regression, longer overall survival was associated with adjuvant chemotherapy (HR ??, 95%CI ??), younger age (<60 years; HR ??, 95%CI ??), and no lymph node metastasis (HR ??, 95%CI ??). In multivariate regression, longer overall survival was independently associated with adjuvant chemotherapy (HR ??, 95%CI ??). Median overall survival was 39 months (interquartile range: 27.1–50.9) in 43 patients who received adjuvant chemotherapy vs. 13 months (interquartile range: 10.1–15.9) in 24 patients who did not receive adjuvant chemotherapy (hazard ratio=0.47; 95% confidence interval: 0.23–0.94; P=.034).

In patients receiving surgery, adjuvant chemotherapy was independently associated with longer overall survival.

今天我们主要修改了标题和摘要部分，后续我们还会用这篇文章和大家一起修改其他部分，比如正文的引言、图表、结果的展现等等。

摘要的第一句话没有改动，作为作业留给大家。欢迎大家留言批评指正~